蝾螈的文献研究摘要 / Publication research summaries · 3 entries
中文内容为资料集译写。每条说明所依据的摘要或正文范围。 / Chinese text is prepared for this collection. Summary evidence is identified for each entry.
Nature全文 PDF解读与编辑伊比利亚肋突螈基因组揭示四足动物再生的新特征
Reading and editing the Pleurodeles waltl genome reveals novel features of tetrapod regeneration
Nature communications · 2017
依据索引收录的作者摘要概括。
Summary based on the indexed author abstract.
以伊比利亚肋突螈 Pleurodeles waltl 代表清单中广义的蝾螈／螈类条目。
Iberian ribbed newt Pleurodeles waltl represents the broad salamander/newt entry.
主要发现 Key findings
伊比利亚肋突螈约20 Gb基因组发现再生相关微RNA与转座元件扩张；基因编辑显示 Pax3 发育作用及不依赖 Pax7 的肌肉再生。
The approximately 20 Gb ribbed-newt genome reveals expanded regeneration-associated microRNAs and transposons; editing demonstrates developmental Pax3 roles and muscle regeneration without functional Pax7.
结论 Conclusions
再生能力的分子机制在蝾螈类内部也有差异，比较基因组可揭示这些差异。
Molecular mechanisms of regeneration vary even among salamanders, making comparative genomics essential for interpreting them.
PNAS全文 PDF巨噬细胞是成年蝾螈肢体再生所必需的
Macrophages are required for adult salamander limb regeneration.
PNAS · 2013
依据作者摘要概括。
Inspected PubMed abstract indexed by Europe PMC; archived full text does not imply full-text review.
主要发现 Key findings
在美西螈中，早期清除巨噬细胞允许伤口闭合，却阻止肢体再生并导致纤维化；巨噬细胞恢复后再次截肢可重新启动再生。
Early macrophage depletion in axolotls allowed wound closure but prevented limb regeneration and produced fibrosis. Regeneration returned after macrophage recovery when the stump was amputated again.
结论 Conclusions
特定时段的免疫细胞活动有助于形成允许再生的环境；伤口愈合并不等同于成功再生。
Timed immune-cell activity helps establish a regeneration-permissive environment; successful healing is not equivalent to successful regeneration.
Science全文 PDF成年脊椎动物肢体再生依赖神经的分子基础
Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate.
Science · 2007
依据作者摘要概括。
Inspected PubMed abstract indexed by Europe PMC; archived full text does not imply full-text review.
主要发现 Key findings
分泌蛋白 nAG 与 Prod1 结合并促进螈类再生芽细胞生长。去神经使正常 nAG 表达消失，而局部表达 nAG 可恢复去神经再生芽的远端结构再生。
The secreted protein nAG binds Prod1 and promotes newt blastema-cell growth. Denervation eliminates normal nAG expression, while local nAG expression rescues regeneration of distal structures in a denervated blastema.
结论 Conclusions
一种明确的分子信号将位置身份与肢体再生对神经的经典依赖联系起来。
A defined molecular signal links positional identity and the classical requirement for nerves during limb regeneration.