中文题名 / Chinese title: 成年脊椎动物肢体再生依赖神经的分子基础
英文题名 / English title: Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate.
作者 / Authors: Kumar A, Godwin JW, Gates PB, Garza-Garcia AA, Brockes JP.
期刊 / Journal: Science
年份 / Year: 2007
DOI: 10.1126/science.1147710
论文链接 / Article: https://doi.org/10.1126/science.1147710
摘要来源 / Abstract source: https://europepmc.org/article/MED/17975060

英文摘要原文 / Original English abstract
The limb blastemal cells of an adult salamander regenerate the structures distal to the level of amputation, and the surface protein Prod 1 is a critical determinant of their proximodistal identity. The anterior gradient protein family member nAG is a secreted ligand for Prod 1 and a growth factor for cultured newt blastemal cells. nAG is sequentially expressed after amputation in the regenerating nerve and the wound epidermis-the key tissues of the stem cell niche-and its expression in both locations is abrogated by denervation. The local expression of nAG after electroporation is sufficient to rescue a denervated blastema and regenerate the distal structures. Our analysis brings together the positional identity of the blastema and the classical nerve dependence of limb regeneration.

摘要依据的主要发现 / Findings based on the abstract
分泌蛋白 nAG 与 Prod1 结合并促进螈类再生芽细胞生长。去神经使正常 nAG 表达消失，而局部表达 nAG 可恢复去神经再生芽的远端结构再生。
The secreted protein nAG binds Prod1 and promotes newt blastema-cell growth. Denervation eliminates normal nAG expression, while local nAG expression rescues regeneration of distal structures in a denervated blastema.

摘要依据的结论 / Conclusions based on the abstract
一种明确的分子信号将位置身份与肢体再生对神经的经典依赖联系起来。
A defined molecular signal links positional identity and the classical requirement for nerves during limb regeneration.

可用全文文件 / Available full-text files