中文内容为资料集译写。每条说明所依据的摘要或正文范围。 / Chinese text is prepared for this collection. Summary evidence is identified for each entry.
Nature全文 PDF小鳐基因组与翼状鳍的演化形成
The little skate genome and the evolutionary emergence of wing-like fins
Nature · 2023
依据索引收录的作者摘要概括。
Summary based on the indexed author abstract.
主要发现 Key findings
小鳐基因组与发育调控实验将翼状胸鳍联系到基因组重排、平面细胞极性通路以及前部胸鳍的 Hox 调控变化。
Skate genomics and developmental experiments link wing-like pectoral fins to genomic rearrangements, planar-cell-polarity signalling and altered anterior-fin Hox regulation.
结论 Conclusions
基因组空间调控的重组是鳐类特殊体型形成的重要机制。
Reorganization of genomic regulation is an important mechanism underlying the distinctive batoid body plan.
PNAS全文 PDF由 Hoxd 全局调控区驱动的附肢表达是有颌类的古老特征
Appendage expression driven by the Hoxd Global Control Region is an ancient gnathostome feature.
Proceedings of the National Academy of Sciences of the United States of America · 2011
摘要解读依据已查看的索引作者摘要；如已保存全文，可用于进一步阅读。
Summary based on the inspected indexed author abstract; archived full text, when available, is provided for further reading.
鳐类增强子作为多物种鳍肢过渡研究的实验比较材料。
Skate enhancer sequences are experimental comparators in a multispecies fin-to-limb study.
主要发现 Key findings
跨物种转基因实验显示，四足动物、斑马鱼及鳐类的同源 Hoxd 增强子能在小鼠肢体与斑马鱼鳍中驱动报告基因表达，因此与附肢远端相关的调控活性早于四足动物肢体出现。
Cross-species transgenic experiments showed that homologous Hoxd enhancer sequences from tetrapods, zebrafish and skate can drive reporter expression in mouse limbs and zebrafish fins. Regulatory activity associated with distal appendages therefore predates the evolution of tetrapod limbs.
结论 Conclusions
四足动物肢体创新部分源于对深度保守 Hox 调控机制的修改，而非完全新建调控系统；本篇以鳐类作为多物种比较实验材料之一。
Tetrapod limb innovations partly arose by modifying deeply conserved Hox regulatory mechanisms, rather than requiring an entirely new regulatory system. Skate is a comparative experimental source within this multispecies study.