中文题名 / Chinese title: BMP 信号对趾间凋亡和鳞片形成的必要作用
英文题名 / English title: Requirement for BMP signaling in interdigital apoptosis and scale formation.
作者 / Authors: Zou H, Niswander L.
期刊 / Journal: Science
年份 / Year: 1996
DOI: 10.1126/science.272.5262.738
论文链接 / Article: https://doi.org/10.1126/science.272.5262.738
摘要来源 / Abstract source: https://europepmc.org/article/MED/8614838

英文摘要原文 / Original English abstract
Interdigital cell death leads to regression of soft tissue between embryonic digits in many vertebrates. Although the signals that regulate interdigital apoptosis are not known, BMPs--signaling molecules of the transforming growth factor-beta superfamily--are expressed interdigitally. A dominant negative type I BMP receptor (dnBMPR-IB) was used here to block BMP signaling. Expression of dnBMPR in chicken embryonic hind limbs greatly reduced interdigital apoptosis and resulted in webbed feet. In addition, scales were transformed into feathers. The similarity of the webbing to webbed duck feet led to studies that indicate that BMPs are not expressed in the duck interdigit. These results indicate BMP signaling actively mediates cell death in the embryonic limb.

摘要依据的主要发现 / Findings based on the abstract
阻断鸡胚后肢 BMP 信号会减少趾间凋亡、产生蹼足并使鳞片转为羽毛。与鸭趾间组织的比较将信号差异与保留蹼膜联系起来。
Blocking BMP signaling in embryonic chicken hindlimbs reduces interdigital apoptosis, produces webbed feet and transforms scales into feathers. Comparisons with duck interdigits link signaling differences to retained webbing.

摘要依据的结论 / Conclusions based on the abstract
发育信号变化可造成羊膜动物附肢形态的显著差异，包括指趾分离及皮肤附属结构。
Changes in developmental signaling can generate major differences in amniote appendage form, including digit separation and skin appendages.

可用全文文件 / Available full-text files